The road team had won the previous five games in this divisional rivalry. The Titans (2-1) are the defending AFC South champs with a healthy Derrick Henry. The reigning AP NFL Offensive Player of the Year ran for 113 yards as he topped the 100-yard mark for a sixth straight divisional game.
The Colts (0-3) are off to their worst start since 2011. Carson Wentz started despite sprained ankles. He never ran and threw for 194 yards.