Emergency crews responded to three separate deadly crashes in three Bootheel counties within a 12 hour time span on Sunday. The crashes were in Butler, New Madrid and Pemiscot Counties. The first crash happened at 5:44 a.m. in New Madrid County on Highway 60, approximately one mile east of Highway 61. Police say Karen G. Steele, 58 of Naylor, was driving an SUV and crashed into the rear of a semi-tractor trailer and she died at the scene. The driver of the semi was not injured in the crash. Police say both drivers were wearing seat belts. At 9:06 a.m. emergency crews responded to a single-vehicle crash on Highway O, approximately one mile east of Interstate 55, in Pemiscot County. Police say 42-year-old Corey L. Vandyke, of Jackson, Tennessee, for an unknown reason, drove his car off the left side of the road. The car hit an embankment and flipped. Vandyke died at the scene. The third crash happened around 5:30 Sunday evening in Butler County. Police say 60-year-old William T. Chambers, of Poplar Bluff, was driving east on Highway 60 when he pulled into the path of an eastbound semi-tractor trailer. The car then hit the semi, went off the left side of the road and flipped and Chambers was killed the crash. The truck driver was not hurt. Police say both drivers were wearing seat belts.